Genome transplantation

An experimental approach which consists of replacing the genetic program of a bacterial cell by a new synthetic genetic program. The fact that the cell readily expresses the new chromosome, in the case of Mycoplasma [1], shows that the genetic program is independent from the cellular machine like in a computer. This is another proof of concept of the cell as a Turing Machine. Like in a computer, in which a program may not run if it is not properly recognized by the machine, one cannot expect any genome transplantation to be productive.


1. Lartigue C, Glass JI, Alperovich N, Pieper R, Parmar PP, Hutchison CA, 3rd, Smith HO, Venter JC (2007) Genome transplantation in bacteria: changing one species to another. Science 317: 632-638